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在小儿桃体切除术后,围手术期的桃体对术后出血的作用
Noah Shaikh1, Amani Kais1, John Dewey1
1Department of Otolaryngology-Head and Neck Surgery, West Virginia University, Morgantown, WV, USA.
International journal of pediatric otorhinolaryngology
|April 23, 2024
概括
在小儿桃体切除术后使用Ketorolac会增加出血并发症的风险. 这项研究发现,接受凯托洛拉克的患者中,需要手术的初级和二级出血的发生率更高.
科学领域:
- 儿科手术 儿科手术
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 凯托洛拉克是一种常见的止痛药,但由于出血问题,在桃体切除术中经常避免使用.
- 这项研究旨在评估儿童桃体切除术患者使用凯托洛拉克的风险.
研究的目的:
- 评估基托洛拉克与手术后出血在接受桃体切除手术的儿童之间的关联.
- 量化需要手术干预的初级和二级出血事件的风险.
主要方法:
- 对TrinetX电子健康记录数据库 (2024年1月) 的回顾性分析.
- 确定的儿科患者 (<18岁) 接受桃体切除术或不进行桃体切除术,不包括出血障碍患者.
- 使用倾向性匹配得分来比较接受凯托洛拉克与未接受凯托洛拉克的队列,评估需要手术控制的出血.
主要成果:
- 17,434名患者接受了凯托洛拉克,290,373名患者没有;倾向性得分匹配创造了分别为17,434名患者的平等队列.
- 凯托洛拉克的使用与明显增加初级出血 (OR 2.158) 和需要操作控制的二次出血 (OR 1.374) 的风险有关.
结论:
- 在小儿桃体切除术中使用凯托洛拉克与手术后出血的风险更高有关.
- 这些发现表明,由于手术出血风险增加,在这种患者群体中使用凯托洛拉克时需要谨慎.
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