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固体器官移植接受者和癌症中的免疫检查点阻断剂:INNOVATED队列队列
J Remon1, E Auclin2, L Zubiri3
1Paris-Saclay University, Department of Cancer Medicine, Gustave Roussy, Villejuif.
ESMO open
|April 23, 2024
概括
免疫检查点阻断剂 (ICB) 在患有晚期癌症的固体器官移植 (SOT) 接受者中显示可行性,在其他人失败时提供治疗选择. 仔细的多学科团队参与是至关重要的,因为潜在的异种移植拒绝风险.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
背景情况:
- 实体器官移植 (SOT) 患者通常被排除在涉及免疫检查点阻断剂 (ICB) 的临床试验之外.
- 随着移植率的增加,需要评估ICB在这种独特患者群体中的疗效和安全性.
- 肺癌是这个群体中一个重要的焦点.
研究的目的:
- 评估免疫检查点阻断剂 (ICB) 治疗在实体器官移植 (SOT) 和实体瘤患者中的结果.
- 专门分析这个队列中的肺癌患者的治疗反应和不良事件.
主要方法:
- 进行了一项多中心回顾性队列研究.
- 从患者的病历中收集了关于ICB使用,临床结果和不良事件的真实数据.
- 关键终点包括整体应答率 (ORR),6个月无进展生存期 (PFS) 和严重的免疫相关不良事件.
主要成果:
- 该研究确定了31名SOT接受者患有固体瘤,其中36%患有肺癌.
- 整体反应率 (ORR) 为45.2%,6个月PFS为56.8%.
- 在25.8%的患者中发生了异构移植排斥,无论ICB策略或治疗反应如何.
结论:
- 免疫检查点阻断剂 (ICB) 是一种可行的治疗选择,可用于缺乏替代方案的SOT接受者,具有先进的固体瘤.
- 在开始ICB治疗之前,所有移植器拒绝的风险强调了需要多学科团队咨询的必要性.
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