结核菌结核病感染在学校结核病例的接触:一个系统的审查和元分析
Wenjin Wang1,2, Aohan Liu3, Xinjie Liu4
1Department of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu Province, Nanjing, People's Republic of China.
The American journal of tropical medicine and hygiene
|April 23, 2024
概括
结核病的传播在家庭之外是显著的,建议学校对Mycobacterium结核病感染进行监测. 一项系统性审查发现,学校接触者感染率为33.2%,这凸显了在高负担地区需要学校查的必要性.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 实质性的结核病传播发生在家庭之外.
- 在学校开展结核病监测是早期检测的策略之一.
- 在学校接触者中结核病结局的流行情况没有得到很好的描述.
研究的目的:
- 评估学校密切接触者中Mycobacterium结核病感染的流行情况.
- 评估基于学校监测的结核病结果的产量.
- 在高负担环境中告知学校接触调查和一般监视的潜力.
主要方法:
- 来自PubMed,Elsevier,中国国家知识基础设施和万芳数据库的研究的系统审查.
- 包括报告M.结核病感染检测结果阳性的儿童数量的研究.
- 根据研究地点,指数病例细菌学状况和学校类型进行了子组分析.
主要成果:
- 分析了28项涉及54,707名学校接触者的研究.
- 结核菌感染的总体流行率为33.2% (QuantiFERON金).
- 结核素皮肤测试 (TST) 的流行率为27.2% (≥5毫米),24.3% (≥10毫米) 和12.7% (≥15毫米).
- 患病率在中国 (22.8%) 低于其他地区 (36.7%),使用TST≥5mm.
- 细菌学上阳性指数病例 (43.6%) 与阴性 (23.8%) 的患病率较高.
结论:
- 学校接触调查和监测对于在儿童中早期发现病例非常有价值.
- 研究结果支持在高负担环境中考虑学校查.
- 在学校接触者中M.结核病感染的流行率需要进一步的调查和干预策略.
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