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Maximilian Robert Justus Wiest¹, Angelika Schuknecht¹, Timothy Hamann¹

¹Department of Ophthalmology, UniversitätsSpital Zürich, Zürich, Switzerland.

Klinische Monatsblatter fur Augenheilkunde

|April 23, 2024

概括

视网膜厚度增加可以帮助识别患有视网膜中枢动脉阻塞 (CRAO) 的患者,这些患者可能会从及时的血栓溶解中受益. 这种非侵入性成像标记在检测治疗治疗的治疗窗口方面表现有前途.

科学领域:

眼科医生眼科眼科
血管神经学血管神经学
医疗成像医学成像

背景情况:

中央视网膜动脉堵塞 (CRAO) 通常导致严重的视力丧失.
对CRAO的既定疗法是有限的.
准确确定症状发作以来的时间对于治疗决策至关重要,但患者病史可能不可靠.

研究的目的:

评估视网膜厚度增加的实用性,作为预测中心视网膜动脉封闭开始的预测标记.
为了评估相对视网膜厚度增加的性能,在血栓溶解的治疗窗口内识别患者.

主要方法:

在瑞士一家医院对41名CRAO患者进行了回顾性研究.
光学连贯断层扫描 (OCT) 用于测量与未受影响的眼睛相比,视网膜相对厚度的增加.
视网膜厚度增加与症状发作时间的相关性,切断值为<24.5%.

主要成果:

分析了42只具有CRAO的眼睛;平均年龄为66.4岁.
在12只眼睛中观察到相对视网膜厚度增加低于24.5%,缺血时间小于4.5小时.
在25只眼睛中发现了超过24.5%的相对视网膜厚度增加,缺血时间>4.5小时,产生高灵敏度 (92.3%) 和特异性 (86.2%).

结论:

相对视网膜厚度增加是一个有价值的非侵入性成像参数,用于在治疗窗口内识别CRAO患者.
这种标记在患者病史不准确时有助于客观评估.
建议对这个参数进行进一步的研究,以便对CRAO进行管理.

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