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在小鼠性肌肉中,内分泌大麻素重塑与催化和代谢调节有关

Sebastiaan Dalle¹, Charlotte Hiroux¹, Katrien Koppo¹

¹Exercise Physiology Research Group, Dept. of Movement Sciences, KU Leuven, Tervuursevest 101, 3001 Leuven, Belgium.

Biochimica et biophysica acta. Molecular basis of disease

|April 23, 2024

概括

癌症缓解症降低了肌肉大麻素受体1 (CB1) 和胺 (AEA) 水平,而运动部分恢复了CB1. 在这种情况下,CB1信号与肌肉代谢和分解有关.

科学领域:

肌肉生理学和内分泌大麻素系统研究.
癌症缓解症及其对骨肌肉的影响.
运动生理学及其对肌肉的分子影响.

背景情况:

癌症缓解症导致不可逆转的肌肉退化.
内分泌系统,特别是CB1受体,影响肌肉新陈代谢和再生.
缓冲症和运动对肌肉内分泌素信号传递的影响在很大程度上是未知的.

研究的目的:

为了研究癌症缓解症和运动对肌肉内分泌素信号传递的影响.
为了确定CB1表达是否与肌肉合成,代谢和新陈代谢标志物相关.

主要方法:

雄性BALB/c小鼠被诱导产生C26结肠癌或PBS控制.
小鼠接受了静止状态或自愿轮子运行 (VWR) 的条件.
肌肉组织分析了内分泌大麻素水平,受体表达和酶活性.

主要成果:

在Cachexic小鼠中,肌肉CB1表达,安纳胺 (AEA) 水平和NAPE-PLD表达显著降低,FAAH表达增加.
运动 (VWR) 增加了肌肉CB1表达和MAGL表达.
CB1表达与肌肉质量,代谢标记物 (p-AMPK,PGC1α) 和代谢标记物 (p-FOXO,LC3b,Atg5) 有正相关.

结论:

癌症缓解症会破坏肌肉内分泌素信号传递,其特征是CB1和AEA的减少.
运动可以部分抵消肌肉CB1信号传递中因卡切西亚引起的变化.
内分泌大麻素系统在肌肉生理学中发挥着重要作用,为缓冲症提供了潜在的治疗点.

关键词:

合成代谢 (Anabolism) 是一种缩性缩症缩性缩症卡切西亚卡切西亚卡切西亚内分泌大麻素系统内分泌大麻素系统运动运动运动.

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