在大鼠中介前额叶皮层中功能横向化控制了情境条件化情绪反应的控制
Lucas Gomes-de-Souza1, Cristiane Busnardo1, Adrielly Santos1
1Laboratory of Pharmacology, São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, Brazil.
Progress in neuro-psychopharmacology & biological psychiatry
|April 23, 2024
概括
右侧中间前额叶皮层 (mPFC) 控制了恐惧调节中的结行为. 在恐惧检索期间的心血管反应由mPFC双边处理,显示功能解离.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 神经生物学 神经生物学 神经生物学
背景情况:
- 中间前额叶皮层 (mPFC) 参与情绪反应控制.
- 已知mPFC在情绪处理中的功能横向化.
- 半球不对称性在mPFC参与恐惧调节是不确定的.
研究的目的:
- 为了研究半球不对称性在中间前额叶皮质 (mPFC) 控制恐惧条件反应.
- 为了确定mPFC控制恐惧检索期间的结和心血管反应是否是侧向的.
主要方法:
- 在mPFC中植入双边或单边导向头的老鼠.
- 在恐惧检索之前,微注射CoCl2 (突触抑制剂) 或载体到mPFC中.
- 记录结行为 (移动,养) 和心血管参数 (动脉压,心率).
主要成果:
- 双边的mPFC抑制减少了结和心血管反应.
- 在右侧的mPFC中单边抑制减少了结,但并没有降低心血管反应.
- 左侧mPFC的单边抑制对结或心血管反应没有影响.
结论:
- 在情境恐惧调节中,mPFC的右半球对于结行为是必要的,也是足够的.
- 在恐惧检索期间控制心血管反应和结行为在mPFC中被解离.
- 在恐惧检索期间的心血管反应由mPFC双边处理.
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