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生命早期的肥胖和脂质失调:对心脏代谢风险的影响
Aleksandra Zeljkovic1, Jelena Vekic1, Aleksandra Stefanovic1
1Department of Medical Biochemistry, University of Belgrade-Faculty of Pharmacy, Belgrade, Serbia.
Metabolism: clinical and experimental
|April 23, 2024
概括
儿童肥胖源于生命早期的表观遗传变化,特别是母亲的新陈代谢变化. 本综述探讨了子宫内和产后暴露如何影响儿童的肥胖和心脏代谢风险.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 儿童肥胖是一个日益严重的全球健康危机.
- 它与严重的心脏代谢问题有关,如胰岛素抵抗,糖尿病和心血管疾病.
- 在产前和产周期间的表观遗传修饰越来越多地涉及到.
研究的目的:
- 审查子宫内/产后暴露与儿童肥胖之间的联系.
- 检查孕产妇脂质不良症在表观遗传变化中的作用.
- 分析肥胖年轻人心脏代谢风险的新型脂质生物标志物.
主要方法:
- 对最近发现的文献综述.
- 专注于表观遗传机制.
- 脂质生物标志物的分析及其临床实用性.
主要成果:
- 受到母亲因素影响的早期代谢编程会影响后代的长期健康.
- 孕产妇的脂质不良是不良表观遗传修饰的一个关键驱动因素.
- 新的脂质生物标志物显示出预测心脏代谢风险的潜力.
结论:
- 针对母亲的新陈代谢和早期生命暴露的干预措施对于预防儿童肥胖至关重要.
- 了解表观遗传影响是解决相关心脏代谢并发症的关键.
- 对脂质生物标记物的进一步研究可以改善风险评估和临床管理.
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