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Updated: Jun 28, 2025

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基于低分子量奇托的GSH响应的自我组装的阴离子微粒通过结合氧化损伤和化疗来增强抗瘤效果

Yuting Yuan¹, Qiuhong Chen², Zhenhua Wang³

¹Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; University of Chinese Academy of Sciences, Beijing 100049, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China.

International journal of biological macromolecules

|April 23, 2024

概括

一种结合化疗和氧化损伤的新型纳米载体提供了增强的抗瘤效果. 这种药物输送系统有效地向癌细胞,释放药物并增加活性氧物种 (ROS),以改善癌症治疗.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

开发先进的药物输送系统对于提高癌症治疗疗效至关重要.
基托桑基纳米载体提供生物相容性和生物降解性.
有针对性的药物释放和组合疗法可以克服耐药性并提高治疗结果.

研究的目的:

构建一种新型的氧化还原敏感阴离子纳米载体 (LCNE-LA),用于联合化疗和氧化损伤.
评估纳米载体的物理化学特性,生物安全性和药物载荷能力.
为了研究多克索鲁比装载纳米载体的体外抗瘤疗效.

主要方法:

脂酸移植素纳米载体 (LCNE-LA) 的合成和特征.
将多克索鲁比辛 (Dox) 封装到LCNE-LA中,以形成Dox/LCNE-LA小粒.
评估药物释放动力学,细胞吸收,活性氧物种 (ROS) 生成和谷氨 (GSH) 消耗.
对癌细胞的体外细胞毒性评估.

主要成果:

杜克斯/LCNE-LA小粒体表现出有利的物理化学特性,包括小尺寸,正泽塔潜力和良好的稳定性.
观察到高效的细胞吸收和对氧化还原敏感的多克索鲁比释放,导致GSH耗尽和氧化还原平衡的破坏.
纳米载体显著增加了细胞内ROS水平,导致癌细胞的氧化损伤.
与自由 doxorubicin 相比,dox/LCNE-LA 菌根在体外表现出优越的抗瘤活性.

结论:

开发的LCNE-LA纳米载体是联合化疗和氧化应激治疗的有希望的平台.
氧化还原敏感药物释放和ROS生成能力提高了抗癌疗效.
这种方法为克服瘤耐药性和改善治疗结果提供了潜在的策略.

关键词:

两胞性结合体两胞性结合体具有GSH反应的阴阳性菌根.低分子量奇托桑 (chitosan) 是一种低分子量奇托桑.

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