状细胞疾病与产后严重孕产妇发病率之间的关联
Natalie E Poliektov1, Danielle M Vuncannon1, Thoa K Ha1
1Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia.
American journal of perinatology
|April 23, 2024
概括
患有状细胞疾病 (SCD) 的个体在分娩期间和产后42天内面临严重孕产妇致病率 (SMM) 的风险明显更高. 在分娩时的活跃危机进一步增加了这种风险,突出了需要专业护理的需要.
科学领域:
- 产科和妇科 产科和妇科
- 血液学 血液学 血液学
- 公共卫生 公共卫生
背景情况:
- 状细胞疾病 (SCD) 是一种遗传性血液疾病,可以影响怀孕的结果.
- 严重的孕产妇发病率 (SMM) 是一个重大的公共卫生问题,包括怀孕或产后出现的危及生命的疾病.
研究的目的:
- 为了比较患有状细胞疾病 (SCD) 的人与没有SCD的人的严重孕产妇发病率 (SMM).
- 评估SMM的风险从分娩入院到产后42天.
主要方法:
- 在城市安全网医院2011-2019年间接受17354次分娩的回顾性队列研究.
- 暴露时间:SCD诊断. 结果:SMM指标的组合 (不包括输血和状细胞危机).
- 根据CDC的定义,使用ICD-9/10代码识别的SMM指标.
主要成果:
- 患有SCD的人患复合SMM的风险增加了6倍 (15.22%对2.29%,p<0.001).
- 在SCD组中观察到急性功能衰竭,ARDS,脑血管疾病,败血症,栓塞和通风的风险增加.
- 在分娩时的活跃血管闭塞危机与SMM的9倍更高的风险相关 (aIRR:8.92).
结论:
- 在分娩入院期间和产后42天内,SCD是SMM的重要风险因素.
- 交付时的活跃危机大大增加了中小企业的风险.
- 在SCD患者中产后SMM主要与呼吸系统事件或败血症有关.
更多相关视频
07:24A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
1.7K
05:31Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
810
相关概念视频
01:49Multiple Allele Traits
34.2K
The Concept of Multiple Allelism
34.2K
02:57Meiosis vs. Mitosis
55.4K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
55.4K
01:19Rh Blood Group
1.4K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.4K
01:25Immunodeficiency Diseases
936
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
936
01:07Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K