酒精依赖的药理疗法:来自英国人口的队列队列的吸收,不平等和比较有效性的证据
Francesco Manca1, Lisong Zhang1, Niamh Fitzgerald2
1School of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom.
Drug and alcohol review
|April 23, 2024
概括
在苏格兰,酒精依赖药物处方方面的不平等存在. 迪苏尔菲拉姆比阿坎普罗沙特更有效,在贫困地区的处方较少,男性也收到更少的处方.
科学领域:
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
- 医疗保健服务研究 医疗服务研究
背景情况:
- 评估了苏格兰对酒精依赖药物的处方患病率.
- 检查了对酒精依赖药物获取的社会经济不平等.
- 对比了阿坎普罗沙特和迪苏尔菲拉姆在酒精依赖治疗中的有效性.
研究的目的:
- 确定酒精依赖药物处方的流行和不平等情况.
- 为了比较Acamprosate与Disulfiram在预防住院治疗中的实际有效性.
- 根据社会经济地位和患者特征,识别处方模式的差异.
主要方法:
- 利用了苏格兰处方和住院病人的全国数据集 (N=19,748).
- 采用后勤回归来分析收到处方的几率和考克斯建模来比较有效性.
- 针对潜在的混因素进行调整,以评估药物对未来与酒精有关的住院治疗的影响 (N=11,239).
主要成果:
- 仅有7%的因酒精使用障碍住院的人在出院后获得了处方.
- 在较不贫困的社会经济群体中,处方率更高.
- 男性和先前住院精神病患者的患者获得处方的几率较低 (OR分别为0.88和0.90).
- 与阿卡姆酸相比,迪苏尔菲拉姆在预防与酒精有关的住院治疗方面表现出更高的有效性 (HRs 0.60-0.81).
- 在更贫困的地区,迪苏尔菲拉姆的处方较少.
结论:
- 苏格兰在酒精依赖处方方面存在显著的不平等.
- 贫困地区的男性和个人收到的处方较少,尤其是disulfiram.
- 迪苏尔菲拉姆在预防再接收方面显示出更高的有效性,但处方模式表明社会经济差异.
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