阻塞性睡眠呼吸暂停儿童的阳性气道压力和代谢标记物
Christopher A Gerdung1, Daniel B Ofosu1, Sara Rodriguez-Lopez1
1Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Respiratory care
|April 23, 2024
概括
阳性气道压力 (PAP) 对患有阻塞性睡眠呼吸暂停 (OSA) 的儿童有一些好处,降低了心率和血压. 然而,对体重指数和其他代谢标志物的影响有限,需要更多的研究.
科学领域:
- 儿科睡眠医学 儿科睡眠医学
- 代谢健康 代谢健康
- 心血管生理学心血管生理学
背景情况:
- 儿童阻塞性睡眠呼吸暂停 (OSA) 越来越多地与代谢综合征有关.
- 对气道压力 (PAP) 对儿科代谢标记物的积极影响的研究正在不断增长.
研究的目的:
- 系统地审查和综合PAP对儿童OSA代谢标志物的影响的证据.
主要方法:
- 系统地搜索5个数据库 (直到2022年8月),使用OSA和儿科代谢标志物的术语.
- 包括16项研究 (15项观察性,1项RCT) 与4项研究的元分析.
- 评估身体质量指数 (BMI),血糖,脂质,心血管和炎症标志物.
主要成果:
- 在PAP开始后,没有观察到BMI的显著变化 (中位数随访12个月).
- 观察到心率和血压的降低 (平均随访时间为4.9个月).
- 改善血糖/脂质控制,肝酶或炎症标志物的证据有限且临床上无意义;结果证据非常低.
结论:
- 关于PAP在儿科OSA中的代谢益处的证据令人鼓舞,但有限.
- 需要进一步的纵向研究来评估长期影响,特别是在肥胖儿童中.
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