与代谢功能障碍相关的脂肪性肝病:最终术语的演变
Piero Portincasa1, Gyorgy Baffy2
1Clinica Medica "A. Murri", Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), Medical School, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, Bari 70124, Italy.
European journal of internal medicine
|April 23, 2024
概括
非酒精性脂肪性肝病 (NAFLD) 正在被新术语取代,如代谢功能障碍相关的脂肪性肝病 (MAFLD) 和代谢功能障碍相关的脂肪性肝病 (MASLD). 这些反映了对与代谢问题相关的肝脏疾病的更深入理解.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
- 医学术语 医学术语 医学术语
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 于1986年创造,是全球最常见的肝脏疾病.
- 近年来,由于对NAFLD病理生理学的理解不断进步,人们已经做出了大量努力来更新NAFLD命名体系.
- 新的术语旨在更好地反映肝硬化和心脏代谢风险因素之间的联系.
研究的目的:
- 讨论最近肝病术语的转变,从NAFLD转为MAFLD和MASLD.
- 突出提出的新术语之间的共同点和差异.
- 强调需要继续研究这些代谢功能障碍相关肝脏疾病的发病,结果和治疗.
主要方法:
- 审查最近的科学文献和关于肝病命名的共识报告.
- 拟议术语的分析:与代谢功能障碍相关的脂肪性肝病 (MAFLD) 和与代谢功能障碍相关的脂肪性肝病 (MASLD).
- 讨论这些命名体系变化对临床实践和研究的影响.
主要成果:
- 两个新的术语,MAFLD (2020) 和 MASLD (2023),已被提议取代NAFLD.
- 这两个新术语都强调了与代谢功能障碍和心脏代谢风险因素的关联.
- 马斯尔德将MAFLD的创新方面纳入其中,尽管概念上的差异仍然存在.
结论:
- 命名体系的变化反映了对肝硬化病的病理生理学基础命名的转变.
- 这些变化影响成人和儿科人口,突出显示了疾病的渐进性质.
- 未来的研究应该集中在新术语下的致病,结果,预防和治疗.
相关概念视频
01:30Liver Physiology
518
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
518
01:24Overview of Lipid Metabolism
1.5K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.5K
01:26Diseases of the Liver and Gallbladder
531
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
531
01:24Liver Regeneration
3.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.3K
01:20Inborn Errors of Metabolism
157
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
157
01:27Protein Import into the Peroxisomes
3.5K
Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
3.5K