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Updated: Jun 28, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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SRY-Box转录因子9通过直接相互作用在瘤中触发YAP核进入

Hui Qian1, Chen-Hong Ding2, Fang Liu1

  • 1Department of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.

Signal transduction and targeted therapy
|April 23, 2024
PubMed
概括

SOX9直接与YAP相互作用,促进其核转位和瘤生长. 针对这种SOX9-YAP与S-A1等的相互作用,抑制了YAP的核导入,并抑制了癌症的进展.

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