炎症途径在部状细胞癌中对化疗放射疗法产生抵抗力
D Martin1,2,3, F Rödel4,5,6, S Hehlgans4
1Department of Radiotherapy and Oncology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany. Martin@med.uni-frankfurt.de.
NPJ precision oncology
|April 23, 2024
概括
甲状腺状细胞癌 (ASCC) 中的化学放射治疗耐药性与特定的炎症途径和免疫细胞变化有关. 了解这些标志物可能会改善ASCC患者的治疗策略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 部平细胞癌 (ASCC) 治疗对化疗放射治疗 (CRT) 的反应是可变的.
- 抗CRT的分子基础及其与瘤免疫力的相互作用尚未完全理解.
研究的目的:
- 在ASCC中全面描述CRT耐药性的分子格局.
- 研究瘤免疫微环境,宿主免疫和CRT效应之间的相互作用.
主要方法:
- 对ASCC患者队列的分子分析,包括免疫组织化学,RNA测序和外周血液免疫分析.
- 基线活检和外围血液免疫细胞的分析,来自接受CRT治疗的患者.
- 基因组丰富分析以确定贫困响应者的丰富途径.
主要成果:
- 丰富IFNγ,IFNα,炎症反应,TNFα信号传递和EMT通路在CRT响应较差的患者中.
- 干扰素诱导的跨膜蛋白1 (IFITM1) 表达与较差的局部区域和远程无转移存活率相关.
- 在CRT后观察到的CD4+T细胞的PD-L1增加和T细胞的HLA-DR增加;调节性T细胞和CXCL2的升高与局部区域控制的减少有关.
结论:
- 组织和周围血液中的特定炎症途径和免疫细胞概况与ASCC中的CRT耐药性有关.
- 这些发现支持将CRT与免疫检查点抑制剂结合的试验的合理性,例如正在进行的RADIANCE试验中的durvalumab.
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