在患有全身性红斑狼的患者的左心室缩功能的二维斑点跟踪回声心脏学
Yuhong Liu1, Shanshan Yin2, Zhiming Lin1
1Department of Rheumatology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Clinical rheumatology
|April 23, 2024
概括
二维斑点跟踪回声心电图 (2DSTE) 在全身性红斑狼 (SLE) 患者中检测出早期的左心室缩性损伤. 通过2DSTE测量的全球纵向菌株 (GLS) 与疾病活性相关,有助于在SLE中对心脏进行评估.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 医疗成像医学成像
背景情况:
- 心脏参与是影响系统性红斑狼 (SLE) 患者预后和死亡率的主要因素.
- 传统的心声回声学参数通常无法检测SLE患者的早期左心室 (LV) 缩功能障碍.
- 早期发现亚临床心肌损伤对于治疗SLE患者至关重要.
研究的目的:
- 评估二维斑点跟踪回声心电图 (2DSTE) 在识别SLE患者早期左心室 (LV) 系统性损伤时的实用性.
- 探索从2DSTE和SLE疾病活动中获得的LV缩功能参数之间的关联.
主要方法:
- 包括38名SLE患者和38名匹配的健康对照.
- 使用系统性红斑狼疾病活动指数 (SLEDAI) 2000评估SLE疾病活动.
- 使用心声学和2DSTE测量常规的LV缩功能参数和LV全球纵向应变 (GLS).
主要成果:
- 在SLE患者和对照人群之间,常规LV功能参数 (例如,射出分数) 没有显著差异.
- 与对照人群相比,SLE患者在所有心脏平面中观察到显著较低的GLS值,通过2DSTE检测到.
- 在SLEDAI得分和GLS值之间发现了显著的相关性,特别是GLS Avg和GLS A4C.
结论:
- 2DSTE,特别是GLS测量,可以在SLE患者中检测出早期的,亚临床的左心室缩功能障碍.
- 在SLE中,GLS作为亚临床心肌损伤和LV功能的有价值指标.
- GLS和SLEDAI之间的相关性表明它在评估SLE中心脏参与和疾病活性方面的潜在作用.
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