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益生菌对胃肠功能和Roux-en-Y胃绕道术后代谢状态的影响:双盲随机试验

Hamid Melali¹, Alimeh Abdolahi², Erfan Sheikhbahaei^1,3

¹Isfahan Minimally Invasive Surgery and Obesity Research Center, Department of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Obesity surgery

|April 23, 2024

概括

在Roux-en-Y胃绕道手术 (RYGB) 后的益生菌补充剂改善了维生素水平和像FBS和HbA1C这样的代谢标记. 虽然有益于胃肠道功能,但益生菌对患者的体重减轻没有显著影响.

科学领域:

腹部外科腹部外科
胃肠病学胃肠病学
微生物组研究微生物组研究

背景情况:

鲁克斯-en-Y胃旁路 (RYGB) 手术可以改变肠道微生物群的组成.
手术后的肠道失调可能会影响胃肠道功能和代谢健康.
了解缓解这些变化的干预措施对于患者的康复至关重要.

研究的目的:

评估益生菌补充剂对胃肠功能的影响.
评估益生菌对RYGB患者代谢状态的影响.
为了研究RYGB与益生菌干预后维生素水平的变化.

主要方法:

一个双盲随机临床试验,涉及135名RYGB候选人.
干预组从手术后一周开始接受益生菌片 (Familact Co.);对照组接受安慰剂.
在干预前和后 (3个月和6个月) 收集的实验室,人体测量和GIQLI问卷数据.

主要成果:

两组都显示显著的BMI下降手术后.
与安慰剂相比,益生菌组在3个月和6个月后显示出明显较低的FBS和HbA1C.
维生素B12水平在益生菌组显著增加,在两个时间点都高于安慰剂.
在干预后,GIQLI分数在两组中都显著改善.

结论:

在RYGB后补充益生菌可以提高维生素B12水平并改善代谢参数 (FBS,HbA1C).
益生菌对胃肠功能有积极的影响,根据GIQLI得分.
益生菌的使用不会显著影响RYGB.之后的减肥结果.

关键词:

腹腔外科手术是什么意思临床试验临床试验是指临床试验的临床试验.我们的肠道微生物群.肥胖问题肥胖问题肥胖的手术是为了减肥.益生菌是一种益生菌.

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