异常功能连接与新诊断的患者的药物反应相关
Haijiao Wang1,2, Ge Tan1, Xiuli Li3
1Department of Neurology, West China Hospital, Sichuan University, Wai Nan Guo Xue Lane 37#, Chengdu, 610041, Sichuan, China.
概括
新诊断的患者在某些区域的大脑活动较高,可能表明对抗药物 (ASM) 的反应不佳. 这一发现表明了预测治疗结果的潜在生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 的研究研究.
- 医疗成像医学成像
背景情况:
- 是一种慢性神经系统疾病,其特点是经常性发作.
- 在新诊断的患者中,预测抗发作药物 (ASM) 反应对于有效治疗至关重要.
- 了解ASM反应的神经相关性对于个性化医学至关重要.
研究的目的:
- 为了研究ASM-naïve NDE患者的局部大脑功能活动和连接.
- 确定与ASM治疗的不同反应相关的神经成像生物标志物.
- 为了区分好控制和不受控制的群体之间的大脑模式.
主要方法:
- 功能磁共振成像 (fMRI) 用于评估大脑活动和连接性.
- 低频波动 (ALFF) 和分数ALFF (fALFF) 的幅度测量了当地的功能活动.
- 基于voxel的中心度 (DC) 和基于种子的功能连接 (FC) 评估了大脑网络强度.
主要成果:
- 与健康对照组 (HC) 和受良好控制的 (WC) 组相比,不受控制的 (UC) 组在左后中心 (PoCG.L) 和左下 (ITG.L) 中呈现出更高的ALFF.
- 在UC组的双边PoCG中观察到更高的DC,而不是HC和WC组.
- 该UC组显示较强的FC在PoCG和ITG.L与部和部区域,而WC组已经减少或类似的FC相比HC.
结论:
- 在ASM-naïve近期经验患者中,大脑功能活动和连接性升高可能预测ASM的反应不佳.
- 这些发现表明,基线神经成像特征可以作为治疗结果的潜在生物标志物.
- 需要进一步的研究来验证这些发现,并探索它们在管理中的临床实用性.
相关概念视频
Arteries of the Lower Limbs
188
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
188
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
287
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
287
Antiepileptic Drugs: Potassium Channel Activators
176
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
176
Antiepileptic Drugs: Glutamate Antagonists
325
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
325
Antiepileptic Drugs: GABAergic Pathway Potentiators
388
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
388


