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肠道微生物和前列腺癌的交叉交互是由饮食中的多不和长链脂肪酸调节的

Gabriel Lachance^1,2,3, Karine Robitaille^1,2, Jalal Laaraj^1,2

¹Laboratoire d'Uro-Oncologie Expérimentale, Oncology Axis, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.

Nature communications

|April 23, 2024

概括

肠道微生物组影响前列腺癌 (PCa) 的进展. 欧米茄-3脂肪酸可以通过调节肠道微生物及其代谢物来减轻PCa的生长,这表明PCa患者的饮食干预措施.

科学领域:

在瘤学瘤学.
微生物组研究微生物组研究
代谢学代谢学代谢学

背景情况:

肠道微生物群在前列腺癌 (PCa) 进展中的作用基本上是未知的.
在PCa患者中,激素治疗的反应是由肠道微生物群调节的.

研究的目的:

调查肠道微生物群对PCa进展的影响.
为了确定参与PCa生长的微生物途径和代谢物.
在PCa中探索omega-3脂肪酸的治疗潜力.

主要方法:

在PCa患者和小鼠模型中,便微生物群α多样性与瘤负担的相关性分析.
从大量PCa患者移植便微生物群 (FMT) 到小鼠.
对侵袭性PCa.肠道微生物相关途径的代谢分析.
使用omega-3脂肪酸补充剂 (MAG-EPA) 对小鼠和前前列腺切除术PCa患者进行干预研究.

主要成果:

减少便微生物群的α多样性与PCa中的瘤负担增加相关.
来自PCa患者的FMT刺激了小鼠的PCa生长,这表明肠道微生物组与癌症的交叉交流.
三种参与长链脂肪酸 (LCFA) 代谢的酶被确定为积极的PCa.
补充omega-3LCFA (MAG-EPA) 减少了小鼠的PCa生长和患者的癌症升级.
补充与减少Ruminococcaceae和增加便丁酸盐相关.

结论:

肠道微生物群的组成和功能与PCa的进展有关.
肠道微生物组与癌症的交叉声会显著影响PCa的生长.
欧米茄-3脂肪酸,可能通过调节肠道微生物代谢物如丁酸盐,为PCa提供治疗策略.

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