mdma辅助心理治疗的副作用:一个系统的审查和元分析
Julia Colcott1,2, Alexandre A Guerin2, Olivia Carter1
1Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, VIC, Australia.
概括
用MDMA辅助心理治疗 (MDMA-AP) 显示出治疗的前景,但与副作用的增加有关,主要是轻微和短暂的. 需要进一步的研究才能充分了解其安全性.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床心理学 临床心理学
背景情况:
- 用MDMA辅助心理治疗 (MDMA-AP) 正在成为精神疾病的潜在治疗方法.
- 关于MDMA-AP在各种指示中的副作用概况的全面数据是有限的.
- 评估现有MDMA-AP试验中副作用报告的质量对于评估其安全性至关重要.
研究的目的:
- 进行第一个MDMA-AP相关副作用的系统审查和元分析.
- 评估已发表的MDMA-AP试验中副作用报告的质量.
- 为了将报告的不良事件与注册数据进行比较.
主要方法:
- 在PubMed,EMBASE,PsycINFO,MEDLINE和CENTRAL的系统文献搜索.
- 包括第2期和第3期MDMA-AP研究,不包括第1期研究.
- 使用CONSORT Harms 2022指导方针进行副作用报告的质量评估,并与clinicaltrials.gov.gov进行比较.
主要成果:
- 与对照组相比,MDMA-AP与第二阶段研究中的副作用 (OR=1.67) 和第三阶段研究中的不良事件 (OR=3.51) 的几率增加有关.
- 大多数报告的副作用都是短暂的,严重程度轻到中等.
- 大多数被纳入的RCT具有高偏差风险,证据确定性非常低至中等.
结论:
- 虽然MDMA-AP与副作用的发病率增加有关,但通常是轻微和短暂的.
- 在目前的MDMA-AP研究中,副作用报告的质量和完整性存在重大限制.
- 需要进一步进行严格的研究,以全面描述MDMA-AP的安全性,并为临床实施提供信息.
相关概念视频
Modeling in Therapy
71
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
71
Antidepressant Drugs: MAOIs and Other Agents
227
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
227
CNS Stimulants: Psychedelic Agents
147
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
147
Electroconvulsive Therapy
37
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
37
Elements Crucial for Effective Psychotherapy
42
Research has highlighted several critical factors that influence the effectiveness of psychotherapy, such as the therapeutic alliance, the therapist, and the client.
The Therapeutic Alliance
The therapeutic alliance refers to the relationship between the therapist and the client. The alliance strengthens when the therapist and the client engage in a nurturing, supportive, trusting, empathetic, and respectful relationship, improving therapeutic outcomes. Therapists must monitor this relationship...
The Therapeutic Alliance
The therapeutic alliance refers to the relationship between the therapist and the client. The alliance strengthens when the therapist and the client engage in a nurturing, supportive, trusting, empathetic, and respectful relationship, improving therapeutic outcomes. Therapists must monitor this relationship...
42
Hallucinogens and Psychedelics
164
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
164


