长期暴露于空气污染和使用电子医疗记录的功能之间的关联:一个横截面研究
David Dillon1, Cavin Ward-Caviness1, Abhijit V Kshirsagar2
1Center for Public Health and Environmental Assessment, United States Environmental Protection Agency, Research Triangle Park, NC, USA.
Environmental health : a global access science source
|April 23, 2024
概括
细颗粒物 (PM2.5) 暴露与功能下降有关 (eGFRcr). 臭氧 (O3) 和二氧化 (NO2) 显示与eGFRcr和CKD诊断的反向关联,表明对慢性病的复杂环境影响.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
背景情况:
- 慢性病 (CKD) 影响超过3800万美国人,不成比例地影响老年人.
- 虽然多因素,但CKD的起源越来越多地与环境暴露有关.
研究的目的:
- 调查估计的膜过率 (eGFRcr) 和CKD诊断与暴露于细颗粒物 (PM2.5),臭氧 (O3) 和二氧化 (NO2) 之间的关联.
- 利用2004-2016年北卡罗来纳州电子健康记录 (EHR) 的随机样本.
主要方法:
- 根据2021年CKD-EPI方程计算eGFRcr,该方程基于血清肌素.
- 污染物数据 (PM2.5,O3,NO2) 来自混合和CMAQ模型,以1年的平均暴露度.
- 使用线性混合和后勤回归模型,调整人口统计和并发病因素.
主要成果:
- 在PM2.5中,四分位数间范围 (IQR) 的增加与eGFRcr的1.63mL/min/1.73m2减少相关.
- 臭氧和二氧化与eGFRcr表现出积极的关联.
- 二氧化与首次CKD诊断相反相关 (aOR:0.77).
结论:
- 一年平均PM2.5暴露与降低eGFRcr.相关.
- 臭氧和二氧化显示与eGFRcr和CKD诊断的反向关联.
- 建议进行进一步的研究,以阐明空气污染和功能障碍之间的关系.
更多相关视频
09:00TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients
Published on: April 13, 2021
4.5K
10:11Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies
Published on: October 22, 2014
19.2K
相关概念视频
Factors Affecting Renal Clearance: Renal Impairment
91
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
91
Methods of Documentation VII: EMR
832
Electronic Medical Records (EMRs) primarily center around electronically documenting patients' health information within a single healthcare organization or practice. They contain essential clinical data related to a patient's medical history, diagnoses, medications, treatment plans, lab results, and other pertinent information relevant to the specific encounter or episode of care. EMRs are designed to streamline documentation and workflow processes within individual healthcare...
832
Statistical Methods for Analyzing Epidemiological Data
363
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
363
