细颗粒物通过NLRP3/caspase-1通路加剧了COPD中吸烟诱导的肺损伤
Chiwook Chung1,2, Suk Young Park1, Jin-Young Huh1,3
1Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, 05505, Seoul, Republic of Korea.
Journal of inflammation (London, England)
|April 23, 2024
概括
微粒颗粒物 (PM2.5) 暴露会增加炎症和细胞死亡,通过热死使慢性阻塞性肺病 (COPD) 在吸烟者中恶化. 这种暴露也会对COPD患者的生活质量产生负面影响.
科学领域:
- 环境健康 环境健康
- 肺部医学 肺部医学
- 细胞生物学 细胞生物学
背景情况:
- 暴露于细颗粒物 (PM2.5) 和香烟烟雾是慢性阻塞性肺病 (COPD) 的危险因素.
- 这些暴露会促进肺炎和细胞死亡,加剧COPD.
- 关于PM2.5和吸烟对COPD的综合影响需要进一步研究.
研究的目的:
- 研究吸烟和PM2.5暴露对COPD的综合影响.
- 探索PM2.5引起的COPD恶化的潜在机制.
- 评估PM2.5对COPD吸烟患者的临床影响.
主要方法:
- 根据吸烟状态,研究了COPD患者的PM2.5和临床参数.
- 利用小鼠肺的模型来监测肺损伤,炎症和在烟雾和PM2.5暴露后的细胞因子释放.
- 在暴露于香烟烟雾提取物 (CSE) 和PM2.5的人类支气管上皮细胞中评估了细胞活力,死亡和烧灭.
主要成果:
- 在目前有COPD的吸烟者中,高PM2.5水平与更差的生活质量得分 (SGRQ-C) 相相关.
- 在小鼠中,联合暴露增加了肺膜破坏,炎症细胞透和促炎细胞因子.
- 在体外,CSE和PM2.5的联合暴露降低了细胞活力,并上调了 pyroptosis 标记物 (NLRP3,caspase-1,IL-1β,IL-18),这被NLRP3沉默逆转.
结论:
- 在COPD中,PM2.5加剧了吸烟引起的呼吸道炎症和通过热致死导致的细胞死亡.
- 从临床角度来看,暴露于PM2.5会降低COPD吸烟者的生活质量.
- PM2.5可能会使患有COPD的吸烟患者的预后恶化.
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