认知储备代理措施的纵向验证:在中国农村社区的队列研究
Hao Chen1,2, Jin Hu1, Shiqi Gui1
1Department of Epidemiology and Health Statistics, School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Guizhou Medical University, Guiyang, China.
Alzheimer's research & therapy
|April 23, 2024
概括
认知储备 (CR) 措施在中国农村老年人中是稳定的和有效的,随着时间的推移,它与认知功能有着一致的积极关联. 积累CR对于在以后的生活中保持认知能力很重要.
科学领域:
- 老年学是一门学科.
- 认知神经科学 认知神经科学
- 公共卫生 公共卫生
背景情况:
- 证据支持认知储备 (CR) 维护认知功能,但对CR代理的纵向验证有限.
- 影响CR稳定性和认知功能的后期生活因素需要进一步调查,特别是在多样化的群体中.
研究的目的:
- 在中国农村地区的老年人中验证认知储备 (CR) 代理的稳定性和纵向有效性.
- 在这个人群中随着时间的推移,探索CR与认知功能之间的关联.
主要方法:
- 用确认因素分析 (CFA) 和测量不变性测试来评估CR代理 (教育,社会支持,爱好,运动) 在两个时间点 (2019年和2022年) 的稳定性.
- 斯皮尔曼相关性和通用估计方程 (GEE) 检查了CR和认知功能 (MMSE) 之间的关联.
主要成果:
- CR代理的CFA结构在时间上表现出稳定性,并接受了配置和度量不变性.
- 在两个评估时期 (T0:r=0.54;T1:r=0.49) 中,在CR和认知功能之间观察到稳定,积极的关系.
- 纵向CR与较高的MMSE得分显著相关 (β=2.25;95%CI=2.012.49).
结论:
- 这项研究提供了强有力的证据,证明了CR代理措施在中国农村老年人中的稳定性和有效性.
- 这些发现强调了在整个生命中建立认知储备的重要性,以便在衰老中维持认知功能.
- 促进CR的干预措施可能对晚年认知健康有益,特别是在服务不足的农村社区.
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