母亲财务问题的发育表观基因组影响
Cyrielle Holuka1,2, Giorgia Menta3, Juan Carlos Caro4,5
1Department of Infection and Immunity, Immune Endocrine Epigenetics Research Group, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Development and psychopathology
|April 23, 2024
概括
早期的逆境,如经济问题,可以改变儿童的表观基因组,影响长期健康. 这些与母亲压力因素相关的表观遗传变化,为疾病易感性提供了洞察力.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发展生物学 发展生物学
- 公共卫生 公共卫生
背景情况:
- 早期的逆境 (忽视,低社会经济地位) 与不良的身体和心理健康结果有关.
- 生命早期的环境可以诱导持久的表观遗传修饰.
- 表观遗传变化是一个潜在的机制,将早期的逆境与以后的生活健康轨迹联系起来.
研究的目的:
- 调查母亲的主要经济问题 (MFP) 和物质剥夺 (MD) 对儿童表观基因组的影响.
- 探索暴露于早期社会经济压力因素的儿童的表观遗传衰老和全基因组修饰.
- 确定潜在的生物学途径,调解早期逆境对长期健康的影响.
主要方法:
- 利用了来自阿文长度研究父母和儿童 (ALSPAC) 队列的数据.
- 使用表观遗传钟测量表观遗传衰老.
- 进行了全表观基因组关联研究 (EWAS),以确定特定的表观基因修饰.
主要成果:
- 母亲主要财务问题 (MFP) 与加速表观遗传衰老的联系很弱.
- 多种食物和药物证明了对儿童基因组的显著,独立的编程效应.
- 从出生到7岁的MFP与7岁时明显的全基因组表观遗传修饰有关,并在15岁时持续存在.
结论:
- 生理过程,特别是表观遗传修饰,部分解释了生命早期的逆境和以后的健康问题之间的联系.
- 母亲压力因素 (MFP/MD) 影响类似的生物途径,表明社会经济地位对疾病的影响机制.
- 了解这些表观遗传关联对于解释整个生命中的疾病易感性和健康轨迹至关重要.
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