计划的卵子冷保存:系统审查和元回归分析
Ayala Hirsch1, Bruria Hirsh Raccah2,3, Reut Rotem1
1Department of Obstetrics & Gynecology, Shaare Zedek Medical Center, Hebrew University School of Medicine, Jerusalem, Israel.
Human reproduction update
|April 24, 2024
概括
计划性卵子冷保存 (POC) 为那些担心与年龄相关的生育能力下降的妇女提供了一个可行的选择. 然而,活产率随着年龄的增加而显著下降,在冷保存中.
科学领域:
- 生殖医学 生殖医学
- 妇科 妇科 妇科 妇科
- 产科 产科 产科 产科 产科
背景情况:
- 越来越多的人对与年龄相关的生育能力下降的认识,引发了对计划性卵子冷保存 (POC) 的兴趣.
- 关于POC结果的数据有限,包括解率,怀孕率和活产率,通常来自小型病例系列.
研究的目的:
- 系统地审查和对计划的卵细胞冷保存的结果进行元分析.
- 评估活产率,回归解率和实验室结果.
- 检查活产率与冷保存中的母亲年龄之间的关联.
主要方法:
- 从PubMed (MEDLINE) 和EMBASE的系统数据库搜索开始到2022年8月.
- 包括10项研究 (1999-2020年) 涉及8750名接受POC的妇女.
- 根据PRISMA 2020指南进行的元回归分析.
主要成果:
- 每位患者的总体活产率为28% (95% CI 0.24-0.33).
- 回归解率为11.1% (±4.7%),平均冷保存年龄为38.1年.
- 40岁以上妇女的活产率为19%,而冷保存时35岁以下妇女的活产率为52%.
结论:
- 计划的卵子冷保存是保持生育能力的可行选择.
- 成功率,特别是活产率,受到冷保存时的年龄的影响,随着年龄的增长而下降.
- 高质量的数据对于了解不同年龄组的POC结果至关重要.
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