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Updated: Jun 28, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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由HepQuant DuO量化的肝功能障碍在预测阿姆普雷洛克赛丁的药理动力学方面优于儿童-普格分类

Jitendra Kanodia1, Hugh Giovinazzo1, Wayne Yates1

  • 1Theravance Biopharma US, Inc., South San Francisco, California, USA.

Clinical pharmacology and therapeutics
|April 24, 2024
PubMed
概括

在肝功能受损的患者中,HepQuant肝功能测试比Child-Pugh得分更好地预测安普列洛克西因药物暴露. 疾病严重性指数和门体系统变流测量为肝病患者提供了更好的剂量优化.

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