味觉功能障碍和长期COVID在中国的COVID-19患者:一个6个月的随访研究
Jie Wei1, Chenghui Lu1,2, Yan Ding1
1Department of Stomatology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Oral diseases
|April 24, 2024
概括
大约20%的COVID-19患者可能会经历长期的COVID口味功能障碍,超过5%的口味变化持续. 补充疫苗可能有助于这些患者的口味恢复.
科学领域:
- 传染性疾病 传染性疾病
- 神经学 神经学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 长期COVID,SARS-CoV-2感染的后急性后续,可以表现为持续的感官功能障碍.
- 味觉功能障碍,或改变味觉感,是一种影响生活质量的症状.
- 了解风险因素和恢复模式对于管理长期COVID症状至关重要.
研究的目的:
- 为了评估长期COVID相关的口味功能障碍的患病率.
- 识别与口味障碍的发病和持续相关的风险因素.
- 评估中国患者的胃口功能障碍的恢复时间表和影响因素.
主要方法:
- 在中国上海对SARS-CoV-2 Omicron感染患者进行了一项横截面研究.
- 在报告口味功能障碍的患者中,在6个月后进行了前性随访.
- 统计分析确定了长期COVID的风险因素和与味道恢复相关的因素.
主要成果:
- 18.48%的患者报告了最初的口味功能障碍.
- 在初始功能障碍患者中,20.37%出现了长期的COVID口味功能障碍,5.56%的症状持续超过6个月.
- 多重口味障碍增加了长期COVID的风险 (OR2.364),而COVID-19疫苗增强剂与改善的口味恢复有关 (HR1.344).
结论:
- 长期COVID口味功能障碍影响了COVID-19幸存者的显著少数人群,其中有一部分人群经历了长期的症状.
- 味觉的早期恢复是常见的,通常在1-3周内.
- 接种COVID-19疫苗,特别是强剂,可能会对味觉恢复产生保护作用.
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