巴西里约热内卢的Mpox疫情:一种翻译方法
Guilherme S Lira1,2, Victor A Ota1,2, Mariana Q S Melo1,3
1Núcleo de Enfrentamento e Estudos de Doenças Infecciosas Emergentes e Reemergentes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.
Journal of medical virology
|April 24, 2024
概括
里约热内卢的Mpox疫情主要影响与男性发生性关系的男性,女性和儿童的发病率显著. 诊断标准可能需要对这些群体进行审查.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 动物传染病Mopox在2022年在全球范围内传播,持续传播到人类.
- 之前在非洲以外的疫情是有限的,这引发了人们对2022年事件不寻常特征的担忧.
研究的目的:
- 调查2022年6月至12月在巴西里约热内卢州爆发的mopox疫情.
- 描述mopox病例的临床特征,人口统计和诊断发现.
主要方法:
- 使用公共卫生保健通知表格对疑似mopox病例进行观察研究.
- 通过MPXV-PCR证实诊断;通过ELISA确定抗OPXVIgG.
- 在七个确诊病例中进行了MPXV基因组测序.
主要成果:
- 在3095例疑似病例中,有816例被证实为mopox (26.3%) 的阳性.
- 确诊病例主要是30多岁的男性,包括与男性发生性关系的男性 (MSM);34.9%的人患有艾滋病毒.
- 女性和18岁以下的个体分别占病例的9.4%和5.4%,具有不同的临床表现.
结论:
- 里约热内卢的Mpox呈现出多样化的,通常是轻微的临床特征,主要是生殖器的病变.
- 女性和儿童的发病率高于通常报告的值得注意.
- 观察到的PCR周期值 (Ct) 的双模分布表明,可能需要对特定组的诊断标准进行修订.
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