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从人类麻疹病例中获得的元基因组样本的纳米孔适应性采样

Charlotte Hewel1, Hanno Schmidt2,3, Stefan Runkel2,4

  • 1Institute of Human Genetics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Journal of medical virology
|April 24, 2024
PubMed
概括

基因组监测对于控制麻疹疫情至关重要. 纳米孔测序提供了完整的病毒基因组数据,解决了短读测序遗漏的结构变异,这对于理解宿主范围变化至关重要.

关键词:
工程和技术的工程和技术.进化 演化 演化 演化 演化 演化 演化 演化基因测绘 基因测绘 基因测绘遗传学 遗传学 遗传学 是一个突变/突变速率 突变/突变速率麻疹病毒 (poxvirus) 是一种病毒.研究和分析方法研究和分析方法.病毒分类 病毒分类

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...