糖尿病奖励中性粒细胞对中性粒细胞外细胞陷的形成通过训练免疫力
Sanjeeb Shrestha1, Yu-Bin Lee1, Hoyul Lee2,3
1Department of Physiology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
Research (Washington, D.C.)
|April 24, 2024
概括
训练有素的免疫力为糖尿病中过度的中性粒细胞外细胞陷 (NET) 形成,损害伤口愈合. 准这种训练有素的免疫力可能为糖尿病并发症提供新的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢性疾病 代谢性疾病
- 细胞生物学 细胞生物学
背景情况:
- 糖尿病与伤口愈合受损有关.
- 中性粒细胞在炎症和免疫系统中起着至关重要的作用.
- 中性细胞外细胞陷 (NETs) 涉及到各种炎症状况.
研究的目的:
- 研究训练免疫在糖尿病诱导的中性粒细胞外细胞陷 (NET) 形成中的作用.
- 阐明糖尿病中性粒细胞中NET原始化背后的代谢和表观遗传机制.
- 探索治疗糖尿病相关炎症并发症的潜在治疗点.
主要方法:
- 在糖尿病条件下 (高葡萄糖) 中性粒细胞代谢重编程的分析.
- 评估乙-辅酶A的积累和基因素乙化.
- 药理上抑制关键酶 (腺5'-三酸盐-酸酶,组织酸转移酶).
- 从糖尿病患者中分离出的中性粒细胞的验证.
主要成果:
- 糖尿病条件诱导中性粒细胞的代谢重编程,增强糖解和脂肪酸氧化.
- 这种重新编程导致了乙-辅酶A的积累和随后的基因素乙化.
- 抑制腺素5'-三酸酸酶和素乙烯转移酶的抑制,取消高葡萄糖诱导的NET原始化.
- 在糖尿病患者的中性粒细胞中证实了受过训练的免疫力,将其与NET原始化联系起来.
结论:
- 训练有素的免疫力调解了糖尿病诱导的中性粒细胞内NET初始化.
- 代谢和表观遗传改变是推动这种现象的关键机制.
- 准中性粒细胞训练的免疫力为糖尿病炎症并发症提供了潜在的治疗途径.
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