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与正常和异常肝功能测试比较孕妇的胎儿和母亲的结果:一项前性观察性研究

Jyotsna Pathak¹, Neeru Goel¹, Sanjeev Kumar Jha²

¹Obstetrics and Gynecology, Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, IND.

|April 24, 2024

概括

患有肝功能异常测试 (LFTs) 的孕妇面临增加的孕产妇死亡风险,尽管胎儿结果仍然相似. 升高的胆红素和氨酸转移酶 (ALT) 预测孕产妇死亡,强调需要及时管理.

科学领域:

产科和妇科产科和妇科
肝病学肝病学是一种肝病学.
围产儿医学围产儿医学

背景情况:

孕妇的异常肝功能测试 (LFT) 需要迅速评估和管理,以减轻孕妇和胎儿的并发症.
妊娠期肝脏内胆固醇症 (IHCP) 是妊娠期间LFT乱的主要原因.

研究的目的:

为了确定异常LFTs的孕妇的胎儿-母亲的结果.
为了比较异常和正常的LFTs的孕妇之间的结果.
为了确定妊娠中异常LFT的患病率和原因.

主要方法:

针对患有异常LFT的孕妇进行前性研究,这些孕妇被转介到产前诊所或被录取为分娩.
具有正常LFT的孕妇的比较组.
评估母亲和胎儿的结果,包括死亡率和发病率.

主要成果:

在9.11%的怀孕中观察到异常的LFT,其中IHCP是最常见的原因.
异常LFT组 (5.5%) 的孕产妇死亡率明显高于正常LFT组 (0%).
虽然胎儿死亡率相似 (5.6%对比4.6%),但胆红素和酸酶 (ALP) 的升高与孕产妇死亡率相关,妊娠年龄,APGAR得分和ALP升高与胎儿死亡率有关.

结论:

怀孕期间异常的LFT显著与增加的孕产妇发病率和死亡率有关.
超大胆血症和阿氨酸转移酶 (ALT) 的升高是孕产妇死亡率的关键预测因素.
胎儿结局在异常和正常LFTs的孕妇之间没有显著差异.

关键词:

异常的肝功能测试测试异常的肝功能测试胎儿的结果.母亲的结果.正常肝功能测试测试正常的肝功能测试.怀孕怀孕怀孕怀孕怀孕

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