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与阿法提尼布治疗相关的双边角膜炎

Ya-Tung Liu¹, Chen-Wei Lin¹, Chi-Chin Sun^2,3

¹Department of Ophthalmology, Chang Gung Memorial Hospital, Chiayi, Taiwan.

Taiwan journal of ophthalmology

|April 24, 2024

概括

阿法提尼布是一种EGFR-TKI,可能导致双边角膜炎. 调整阿法提尼布剂量和使用眼滴可以解决这种眼部副作用.

科学领域:

在瘤学瘤学.
眼科医生眼科眼科
药理学药理学是指药理学的学科.

背景情况:

阿法替尼是一种不可逆转的表皮生长因子受体-铁氨酸激酶抑制剂 (EGFR-TKI),用于癌症治疗.
鼻癌 (NPC) 是一种头癌.
眼部的副作用是EGFR-TKI治疗的潜在并发症.

研究的目的:

在患有晚期鼻癌的患者中报告可能由阿法提尼布诱导的双边角膜炎病例.
描述这种眼部不良事件的临床表现,管理和结果.

主要方法:

一个52岁的男性患者的案例研究,患有第四阶段鼻癌,正在接受阿法替尼治疗.
临床检查,包括视敏度评估和裂纹灯生物显微镜.
监测眼部症状和对阿法提尼布剂量修改和支持性眼部水分的反应.

主要成果:

患者患有双边角膜炎,其特征是视力敏度降低,干燥和敏感,与阿法替尼布剂量增加相吻合.
眼部检查显示表面点状角膜病变和上皮缺陷.
症状在降低阿法替尼布的频率和实施密集的眼部滑后得到缓解.

结论:

阿法提尼布是一种EGFR-TKI,与诱导双边角膜炎的风险有关.
早期调整阿法提尼布剂量和支持性眼部护理可以有效地控制和逆转这种副作用.
这一案例强调了监测阿法替尼布治疗患者的眼睛毒性的重要性.

关键词:

亚法替尼 (Afatinib) 是一种药物.皮肤生长因子受体-铁氨酸激酶抑制剂皮质炎是一种皮质炎.

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