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生成的硫化和氧化活动的组合对西斯提诱导的毒性有潜在的保护作用
Faria Khurshid1, Javeid Iqbal1, Fiaz-Ud-Din Ahmad2
1Department of Pharmacology, Faculty of Pharmacy, University of Balochistan, Pakistan.
在大鼠中,硫化 (NaHS) 和L-氨酸可以防止西斯普拉丁诱导的损伤. 结合NaHS和L-氨酸提供了增强的保护,表明协同作用的抗炎和抗氧化作用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學.
- 毒理学 毒理学 毒理学
背景情况:
- 西斯是一种重要的化疗药物,具有显著的毒性.
- 硫化 (H2S) 和氧化 (NO) 具有细胞保护性.
- NaHS和L-氨酸分别是H2S和NO的外部来源.
研究的目的:
- 为了研究NaHS和L-氨酸的保护作用,单独和组合,对西斯普拉丁诱导的毒性在老鼠模型.
- 评估这些药物对功能和氧化应激标志物的影响.
主要方法:
- 威斯塔尔京都的老鼠接受了西斯普拉丁 (5毫克/公斤),随后接受了NaHS (56微摩尔/公斤) 或L-氨酸 (1.25克/升) 治疗28天.
- 分析了血,尿液和脏样本,以检测生物化学和本病理学变化.
- 关键参数包括体重,尿量,血肌素,尿素,电解质,功能标志物和氧化应激指标 (超氧化物失调酶,).
主要成果:
- 西斯普拉丁诱导显著的毒性,体现为体重减轻,尿量增加,肌素和尿素升高,电解质减少.
- 氧化应激标志物发生了变化,超氧化脱酶减少,甲增加.
- 西斯也降低了血和尿液中的H2S和血NO水平.
- 无论是NaHS和L-氨酸治疗都部分扭转了这些西斯胺诱导的效应.
- 组合疗法显示了所有测量参数的更明显的逆转.
结论:
- 作为单一疗法,NaHS和L-氨酸都表现出对西斯普拉丁诱导的毒性有保护作用.
- NaHS和L-氨酸的组合提供了卓越的保护,这表明当它们一起使用时,抗炎和抗氧化潜力得到了增强.
- 这些发现表明,有希望的治疗策略可以缓解西斯普拉丁诱导的损伤.
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