费拉格林基因突变状态和预防无氧性皮肤炎与孕产妇益生菌补充
Dinastry Pramadita Zakiudin1, Jacob P Thyssen2, Claus Zachariae3
1Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway; Clinic for Laboratory Medicine, St Olavs Hospital, Trondheim, Norway. dinastry.p.zakiudin@ntnu.no.
Acta dermato-venereologica
|April 24, 2024
概括
孕产妇的益生菌可以预防婴儿的亚托邦性皮炎,无论菲拉格林基因 (FLG) 突变如何. 这一发现支持益生菌用于高风险新生儿的过敏预防.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 遗传学 是一个遗传学.
- 皮肤病学 皮肤病学
背景情况:
- 世界过敏组织建议使用益生菌来预防高风险婴儿的亚托皮炎.
- 费拉格林基因 (FLG) 突变损害了皮肤屏障,增加了亚托皮炎风险.
- 在特朗德海姆儿童中预防过敏的益生菌 (ProPACT) 研究探讨了益生菌的疗效.
研究的目的:
- 调查母体益生菌补充剂是否可以预防有或没有 filaggrin基因 (FLG) 突变的儿童的亚托皮炎.
- 分析FLG突变状态与亚托皮肤炎风险之间的关联.
- 为了确定益生菌的益处是否根据FLG基因型不同.
主要方法:
- 从ProPACT研究中对228名儿童进行了三种常见FLG突变 (R501X,R2447X,2282del4) 的DNA分析.
- 与母亲的益生菌摄入量和儿童的FLG突变状态相关的亚托皮炎发病率的评估.
- 使用风险比率 (RR) 和置信区间 (CI) 的统计分析.
主要成果:
- 总体而言,7%的儿童携带异性FLG突变,每个孩子只有一个突变类型.
- FLG突变状态与亚托皮性皮炎风险没有显著关联 (RR=1.1;95% CI 0.5至2.3).
- 孕产妇的益生菌降低了亚托皮性皮炎风险 (RR=0.6;95% CI 0.4~0.9),在患有FLG突变 (RR=0.6;95% CI 0.1~4.1) 和野生型FLG (RR=0.6;95% CI 0.4~0.9) 的儿童中观察到类似的效果.
结论:
- 孕产妇服用益生菌补充剂显示,对婴儿的亚托皮炎有预防作用.
- 这种预防效应在具有和没有 filaggrin基因 (FLG) 突变的儿童中似乎是一致的.
- 需要更大规模的证实性研究来验证这些发现并建立临床建议.
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