系统综述和元分析:抑郁症对炎症性肠病预后的影响
Yuejin Ji1, Hongxiao Li2, Guoliang Dai1
1Department of Clinical Pharmacology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
抑郁症显著恶化了炎症性肠病 (IBD) 患者的预后,增加了发作,住院和医疗干预的风险. 这种关联在性结肠炎和克罗恩病亚型之间有所不同.
科学领域:
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
- 临床医学 临床医学
背景情况:
- 抑郁症是患有炎症性肠病 (IBD) 的患者常见的并发症.
- 抑郁症对IBD患者的长期预后和病程的影响仍然是显著的临床兴趣领域.
研究的目的:
- 系统地调查抑郁症对炎症性肠病 (IBD) 预后的影响.
- 量化抑郁症与IBD患者各种不良预后结果之间的关联.
主要方法:
- 在Medline,Embase,Web of Science和PsycINFO数据库中进行了全面的系统文献搜索,截至2023年12月31日.
- 包括的研究集中在抑郁症对IBD预后的影响上,分析了诸如爆发,住院,再入院,急诊,手术和医疗治疗升级等结果.
- 计算了相对风险 (RRs),以评估这些关联的规模.
主要成果:
- 对24项涉及超过63万IBD患者的研究 (14队列,10例对照) 的分析表明,抑郁症显著增加IBD爆发的风险 (RR=1.37),住院 (RR=1.11),再入院 (RR=1.32),急诊 (RR=1.33),手术 (RR=1.38),和治疗升级 (RR=1.38).
- 对于性结肠炎患者来说,在再入院 (RR=1.38) 和治疗升级 (RR=1.78) 方面注意到了特定的关联.
- 患有抑郁症的克罗恩氏病患者出现发作 (RR=1.47) 和住院 (RR=1.20) 的风险增加.
结论:
- 这些发现强烈表明,抑郁症是炎症性肠病 (IBD) 患者预后较差的重要危险因素.
- 抑郁症和IBD预后之间的关系受到IBD的特定亚型的影响,这突显了需要量身定制的管理策略的需要.
更多相关视频
06:55An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Depression: Overview
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
