以前的E型肝炎病毒感染与自身免疫性肝炎患者的肝硬度增加有关
Maciej K Janik1, Agnieszka Kempińska-Podhorodecka2, Joanna Raszeja-Wyszomirska1
1Department of Hepatology, Transplantology and Internal Medicine, Medical University of Warsaw, Warszawa, Poland
Polish archives of internal medicine
|April 24, 2024
概括
自身免疫性肝炎患者对乙型肝炎病毒 (HEV) IgG抗体呈阳性,患有晚期肝纤维化风险增加. 然而,这些患者的HEV血清流行率低于一般人群.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 自身免疫性肝炎 (AIH) 是一种慢性肝病,通常需要免疫抑制.
- 肝炎E病毒 (HEV) 引起急性肝炎,但在免疫功能低下的人群中可能变为慢性.
研究的目的:
- 调查HEV血清阳性对AIH临床进展的影响.
- 在AIH患者中评估HEV感染和肝纤维化之间的关联.
主要方法:
- 分析了374名成年AIH患者的队列.
- 使用ELISA测量了HEV IgG和IgM抗体.
- 肝纤维化通过肝硬度测量 (LSM) 和组织学来评估.
主要成果:
- 15%的AIH患者是HEV IgG阳性,呈现出老年和较高的LSM.
- HEV IgG 血清阳性与晚期肝纤维化风险增加相关 (OR 3.69).
- 在HEV IgG状态和AIH治疗或结果之间没有发现任何联系. 而HEV的血清流行率低于波兰献血者.
结论:
- 具有HEV IgG阳性的AIH患者面临更高的晚期肝纤维化风险.
- 在波兰,AIH患者中HEV IgG的总体血清流行率与普通人群相比较低.
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