肠道微生物群及其与西班牙人口早期血管衰老的关系 (MIVAS研究)
Rita Salvado1, Sandra Santos-Minguez2, Cristina Lugones-Sánchez1,3
1Unidad de Investigación de Atención Primaria de Salamanca (APISAL), Gerencia de Atención Primaria de Salamanca, Gerencia Regional de Salud de Castilla y León (SACYL), Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.
European journal of clinical investigation
|April 24, 2024
概括
早期的血管衰老与特定的肠道细菌有关. 在早期血管衰老的个体中,发现比洛菲拉属的丰富性更高,这表明肠道微生物群在这种情况中可能发挥作用.
科学领域:
- 心血管健康 心血管健康
- 微生物组研究 微生物组研究
- 老龄化研究研究.
背景情况:
- 肠道微生物群在心血管疾病中起着重要作用.
- 了解肠道微生物对血管衰老的影响对于预防策略至关重要.
研究的目的:
- 调查肠道微生物群组成和早期血管衰老 (EVA) 之间的关联.
- 为了确定与加速血管衰老相关的特定微生物模式.
主要方法:
- 这是一项针对180名45-74岁的西班牙成年人进行的横截面研究.
- 早期血管衰老 (EVA) 是通过高脉冲波速度测量来定义的 (cf-PWV,CAVI,ba-PWV).
- 用便样本的16S rRNA Illumina测序分析了肠道微生物组的组成.
主要成果:
- 早期血管衰老 (EVA) 组的平均年龄高于正常血管衰老 (NVA) 组.
- 发现特定的细菌属,包括Bilophila,在EVA组中增加.
- 后勤回归分析证实了Bilophila丰富度和早期血管衰老之间的显著正相关性 (OR: 1.71).
结论:
- 早期血管衰老 (EVA) 与西班牙人口中肠道细菌Bilophila属的丰富性增加有关.
- 在整体肠道微生物群群丰富性或多样性测量和早期血管衰老之间没有发现显著的关系.
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