在青少年和成年人中,A型肝炎血清阳性与骨矿物密度之间的关联:使用NHANES数据的横截面研究
Zhuowen Yu1, Gunchu Hu2, Jiajie Wang3
1Doctoral student, Physician. Department of Orthopedics, Second Xiangya Hospital of Central South University, Changsha, China; Hunan Key Laboratory of Tumor Models and Individualized Medicine, Second Xiangya Hospital of Central South University, Changsha, China.
Sao Paulo medical journal = Revista paulista de medicina
|April 24, 2024
概括
甲型肝炎感染与青少年和成人骨矿物质密度 (BMD) 的降低有关. 这表明,在肝炎A血清阳性患者中,骨质疏松症的风险可能会增加.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 骨健康 骨健康 骨健康
背景情况:
- 骨质疏松症是一种严重的健康问题,其特点是骨密度降低和骨折风险增加.
- 早期检测和预防对于治疗骨质疏松症和减轻骨折并发症至关重要.
研究的目的:
- 检查青少年和成人肝炎A血清阳性和骨矿物密度 (BMD) 之间的关联.
- 探索甲型肝炎感染与患骨质疏松症的风险之间的潜在联系.
主要方法:
- 从国家健康和营养检查调查 (NHANES) (2011-2018) 中对15693名参与者的横截面分析.
- 采用多变量回归分析和独立的z测试来比较甲型肝炎阳性和阴性血清组之间的BMD,并对共变量进行调整.
主要成果:
- 在青少年和成年人群中,A型肝炎病毒阳性个体与血清阴性个体相比,表现出较低的BMD.
- 在血清阳性参与者 (P <0.01) 中观察到腰椎BMD (平均差异=-0.03g/cm2) 和骨盆BMD (平均差异=-0.02g/cm2) 的显著减少.
结论:
- 乙型肝炎的阳性与青少年和成人骨矿物质密度降低有关,特别是在成年人群中.
- 这些发现表明,A型肝炎感染与骨质疏松症风险增加之间存在潜在的关联.
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