亲肠道营养中补充托芬可以增加黑激素并减轻炎症反应吗?
Necdet Fatih Yaşar1, Bartu Badak1, Mustafa Salış2
1Osmangazi University, Faculty of Medicine, Department of General Surgery - Eskişehir, Turkey.
腹腔营养增加了腹部大手术后患者的三和黑激素水平. 这些变化发生在不考虑炎症反应的情况下,根据介质素-1,介质素-6和c-反应蛋白来衡量.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 手术营养是指手术营养.
背景情况:
- 托芬是一种必需的氨基酸,是氨酸的前体.
- 黑色素在睡眠调节中起作用,并具有抗炎性质.
- 大型腹部手术和食物限制会影响新陈代谢和炎症途径.
研究的目的:
- 为了比较经过重大腹部手术的患者的托芬和黑激素水平,与对照组相比,有亲肠道营养.
- 研究托芬和黑激素水平与关键炎症标记物 (互白素-1,互白素-6,C反应蛋白) 之间的关系.
- 评估门营养治疗在手术后对这些参数的影响.
主要方法:
- 一项涉及40名年龄在18-65岁之间的患者的病例控制研究.
- 在基线 (48小时手术前) 和手术后的1,3,5天采集血液和尿液样本.
- 测量血清托,黑激素,联素-1,联素-6和c-反应蛋白水平.
主要成果:
- 在亲肠道营养组中,托芬水平更高,尽管在统计学上并不显著.
- 在这两组中,手术后的黑色素水平都增加了,在经过手术后的第三天,亲肠道营养组的水平在统计学上显著增加.
- 手术后的第3天,干白素-1水平显示出最大的差异;干白素-6在治疗组的第3天略高;在两组之间没有观察到c-反应性蛋白的显著差异.
结论:
- 腹腔营养治疗导致腹部大手术后托芬和黑激素水平增加.
- 观察到的托和黑激素的增加独立于测量的术后炎症反应.
- 进一步的研究可能会探索这些代谢变化对手术患者的临床影响.
更多相关视频
00:04A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
12:02Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
Published on: July 30, 2016
相关概念视频
Management of Insomnia
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
![Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F63025.jpg&w=3840&q=50)