后COVID-19综合征,炎症和胰岛素抵抗:一个回顾性队列研究
Patricia Fierro1, David Martín2, Emilio Pariente-Rodrigo3
1Camargo Interior Primary Care Center, Cantabrian Health Service, Muriedas, Spain.
后COVID-19综合征 (PCS) 与胰岛素耐药性 (IR) 的增加有关,特别是在具有低基线IR的人群中. PCS和IR都与炎症相关,这表明COVID-19引发的潜在炎症状态.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- COVID-19可能导致新的内分泌并发症,如糖尿病.
- 后COVID-19综合征 (PCS) 是一种复杂的疾病,具有新出现的代谢影响.
- 在COVID-19后轻度的非糖尿病人中,PCS和胰岛素抵抗 (IR) 之间的关系需要进一步调查.
研究的目的:
- 评估后COVID-19综合征 (PCS) 和胰岛素抵抗 (IR) 之间的关联.
- 探索炎症在COVID-19感染后IR发展中的作用.
主要方法:
- 采用重复措施设计,进行三次评估:COVID前,COVID后3个月和COVID后21个月.
- 评估了112名非糖尿病门诊患者的PCS,胰岛素耐药性 (使用甘油三指数-葡萄糖指数,TyG) 和炎症 (使用白蛋白与血球蛋白比率,AGR).
- 参与者被分为COVID-19后综合征阳性 (PCS+) 和阴性 (PCS-) 组.
主要成果:
- 具有非常低基线IR (TyG <7.78) 的PCS+个体随着时间的推移显示TyG增加 (P=0.018) 和炎症减少.
- 具有高基线IR (TyG ≥8.65) 的PCS+个体没有表现出显著的TyG变化,但具有更大的炎症负荷.
- 多变量模型表明,PCS是增加TyG的一致预测因素,即使经过对混因素进行调整.
结论:
- 后COVID-19综合征 (PCS) 与胰岛素耐药性 (IR) 的增加有关,特别是在最初IR较低的个体中.
- 无论是PCS还是升高的IR都独立地与炎症有关.
- 急性COVID-19和PCS可能代表潜在炎症状态的临床表现,这也可能导致IR.
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