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Updated: Jun 28, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
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Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

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光脱碳氧化基级联 涉及Pyrazolones合成的N-Acyloxy-phthalimides,用于Pyrazolones的合成

Satya Prakash Panda1, Rupashri Dash1, Sudhir Kumar Hota1

  • 1Department of Chemistry, Indian Institute of Technology Jodhpur, Karwar, 342037 Rajasthan, India.

Organic letters
|April 24, 2024
PubMed
概括

研究人员开发了一种新方法,通过光诱导的激素级联反应来合成基化pyrazolones. 这种方法在温和的无金属条件下利用了新型托西尔化骨架和易于获得的基替代物.

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Acid Halides to Esters: Alcoholysis

Alcoholysis is a nucleophilic acyl substitution reaction in which an alcohol functions as a nucleophile. Acid halides react with alcohol to produce esters. The mechanism proceeds in three steps:
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Chain-growth or addition polymerization is successive addition reactions of monomers with a polymer chain. In radical chain-growth polymerization, the reaction proceeds via a free-radical intermediate. The free radical is formed from radical initiators, which spontaneously generate free radicals by homolytic fission. Organic peroxides (such as dibenzoyl peroxide, as shown in Figure 1) or azo compounds are popular radical initiators. A low concentration ratio of radical initiator to monomer is...
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Another method of radical formation is the elimination process. It is the opposite of the addition route and is driven by the instability of the radical. For example, as depicted in Figure 1, dibenzoyl peroxide yields a pair of unstable radicals upon homolysis. Given its instability, this radical spontaneously undergoes elimination via a C–C bond cleavage to form a relatively more stable phenyl radical. The mechanism involves cleavage of the bond between the α and β positions...
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