在急性化中毒患者中使用油性溶液进行胃肠道消毒:系统性审查和元分析
Amal S A F Hafez1, Fatma M Elgazzar1, Zahraa K Sobh2
1Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Critical reviews in toxicology
|April 24, 2024
概括
以油为基础的胃肠道消毒,特别是用油,在急性化 (AlP) 中毒患者中显著降低了死亡率和输管率. 与传统的胃洗相比,这种方法改善了生存结果.
科学领域:
- 毒理学 毒理学 毒理学
- 紧急医疗 紧急医疗
- 胃肠病学 胃肠病学
背景情况:
- 急性酸 (AlP) 中毒是全球严重的健康问题,死亡率高.
- 胃肠道 (GIT) 消毒是一种关键的干预措施,但最佳方法仍在争论中.
- 之前的研究表明,以油为基础的清除污染对ALP摄入有潜在的益处.
研究的目的:
- 为了比较油性胃洗与非油性方法对急性AlP中毒的疗效和安全性.
- 评估诸如死亡率,输管,血管压缩剂使用和生存时间等结果.
主要方法:
- 针对到2023年9月16日发表的随机对照试验 (RCT) 进行了系统的文献搜索.
- 搜索的数据库包括MEDLINE/PubMed,科克伦图书馆,科学网,Scopus和谷歌学者.
- 用风险比率 (RR) 和标准化平均差异 (SMD) 来提取和聚合数据,并使用95%的置信区间 (CI).
主要成果:
- 七个RCT被纳入了元分析.
- 油显著降低了死亡率 (RR=0.59),输管 (RR=0.59) 和血管压缩剂的需要 (RR=0.71),并延长了生存时间 (SMD=0.72).
- 子油也显示了益处,降低了输管风险 (RR=0.78) 和延长了生存时间 (SMD=0.83).
结论:
- 以油为基础的GIT清除污染,特别是用油,在处理急性AlP中毒时,与传统洗相比,具有显著的优势.
- 建议在ALP中毒脱污时使用油,因为它已被证明可以降低死亡率和改善生存率.
- 需要进一步的大规模临床试验来确认成本效益和安全性.
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