识别肠道微生物组特征,预测对能够增加吸收的益生菌的反应:试点研究
Owen Ma1, Arindam Dutta2, Daniel W Bliss2
1Electrical Engineering, Arizona State University, 650 E Tyler Mall, Tempe, AZ, 85281, USA. owenma@asu.edu.
Calcified tissue international
|April 24, 2024
概括
益生菌可以改善的吸收,改善骨健康,但并非所有孩子都能接受. 基线肠道微生物组分析可以很准确地预测哪些青少年将从益生菌补充剂中受益.
科学领域:
- 营养科学 营养科学
- 微生物组研究 微生物组研究
- 儿童骨健康 儿童骨健康
背景情况:
- 益生菌显示出增强青少年吸收的潜力,这对骨健康至关重要.
- 对前生物干预的个体反应各不相同,需要确定预测因素.
- 了解肠道微生物组的组成是个性化益生菌策略的关键.
研究的目的:
- 为了确定基线肠道微生物组合是否预测青少年对预微生物干预吸收的反应.
- 为了确定与增加吸收相关的特定微生物种群在益生菌补充剂后.
- 开发一个预测模型来识别可能从益生菌中受益的个体.
主要方法:
- 第二次分析比较了响应和不响应可溶性玉米纤维 (SCF) 的肠道微生物群.
- 使用双稳定同位素方法测量了分数吸收.
- 16S rRNA基因测序描述了肠道微生物群,机器学习模型根据基线数据预测了响应能力.
主要成果:
- 使用19个微生物特征的预测模型准确地识别了96.0%的平均准确度的响应者.
- 在响应者和非响应者之间观察到相对类型丰度的显著差异.
- 这些发现突出了基于微生物组的预先选对益生菌有效性的潜力.
结论:
- 基线肠道微生物组组成可以预测青少年对增强吸收的益生菌的反应.
- 微生物组分析提供了一种潜在的方法,用于预先选可能受益于骨健康的益生菌干预的个体.
- 需要进一步研究在发育过程中影响吸收的代谢和遗传因素.
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