尿液中的分泌与哺乳期和骨矿物质密度的关系 - 产后纵向研究
Catarina Magnusson1, Hanna Augustin2, Ravin Jugdaohsingh3
1Department of Orthodontics, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, PO Box 450, 405 30, Gothenburg, Sweden. catarina.magnusson@gu.se.
Biological trace element research
|April 24, 2024
概括
尿液中的 (Si) 排泄可能会在哺乳期妇女中增加产后,但这种变化与骨矿物质密度无关. 需要进一步的研究来了解.
科学领域:
- 生物化学 生物化学
- 人体生理学 人体生理学
- 矿物质的新陈代谢.
背景情况:
- (Si) 是一种可能有益于骨健康的矿物质.
- 怀孕和哺乳期由于矿物质需求增加,显著影响母亲的骨代谢.
- 已知在怀孕期间尿液中的 (Ca) 和Si分泌量很高,产后数据有限.
研究的目的:
- 为了研究从怀孕晚期到产后18个月的尿液Si排泄 (U-Si).
- 为了将U-Si的变化与哺乳期的持续时间相关联.
- 为了确定U-Si变化与产后母体区域骨矿物密度 (aBMD) 之间的关联.
主要方法:
- 长度研究56名妇女完成产后随访.
- 在妊娠的第三个季度和分娩后的0.5,4,12和18个月收集点滴尿样.
- 使用ICP-OES对尿中的Si和Ca进行分析;aBMD通过双能X射线吸收计测量腰椎和大腿部.
主要成果:
- 哺乳期≥4个月的妇女在产后4个月的U-Si显着更高,相比于第三季度.
- 在肌素校正后,没有观察到U-Si的显著纵向差异.
- 在U-Si和aBMD的变化之间没有发现一致的相关性,在一个子组中,在腰椎的小例外.
结论:
- 在哺乳期持续4个月或更长的妇女中,尿液中的Si分泌可能会在分娩后增加.
- 产后的U-Si变化似乎与母亲aBMD的变化没有显著关系.
- 需要进一步研究在哺乳期母亲骨健康中的作用.
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