在扩散性大B细胞淋巴瘤中循环瘤DNA:从长椅到床边?
Hua-Jay J Cherng1, Alex Herrera2
1Lymphoma Service, Division of Hematology & Oncology, Columbia University Irving Medical Center, 177 Fort Washington Avenue, 6GN-Rm 435, New York, NY, 10032, USA. hjc2157@cumc.columbia.edu.
Current treatment options in oncology
|April 24, 2024
概括
循环瘤DNA (ctDNA) 显示出通过评估瘤负担,反应和残留疾病来个性化扩散大B细胞淋巴瘤 (DLBCL) 治疗的希望. 这种生物标志物可以指导治疗决策并改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 血液学恶性瘤是什么
背景情况:
- 由于疾病异质性的表征不足,扩散性大B细胞淋巴瘤 (DLBCL) 的治疗往往是标准化的.
- 目前的诊断工具在充分理解DLBCL复杂的临床和分子特征方面存在局限性.
- 需要个性化医疗方法来改善DLBCL患者的可变结果.
研究的目的:
- 审查循环瘤DNA (ctDNA) 测序用于个性化DLBCL护理的潜力.
- 探索ctDNA测定在各种DLBCL治疗环境中的实用性.
- 倡导将ctDNA纳入DLBCL的临床试验和实践.
主要方法:
- 审查关于ctDNA测定及其在DLBCL中的应用的当前文献.
- 讨论ctDNA在风险分层,分子反应评估和最小残留疾病 (MRD) 监测中的作用.
- 探索包含ctDNA生物标记物的潜在临床试验设计.
主要成果:
- ctDNA测序是一种正在发展中的技术,具有DLBCL管理的巨大潜力.
- 证据支持ctDNA用于估计瘤负担,液体基因型定型和评估治疗反应的实用性.
- ctDNA可以监测MRD,识别耐药性,并预测DLBCL患者的复发.
结论:
- ctDNA测序为个性化DLBCL治疗策略提供了一个有希望的途径.
- 将ctDNA集成到临床试验中对于患者选择和响应适应设计至关重要.
- 使用ctDNA的液体活检可以指导临床决策,特别是当成像是模两可的或在严重毒性时.
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