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Updated: Jun 28, 2025

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在阻塞性睡眠呼吸暂停中,微观结构性脑部异常和相关的神经认知功能障碍:一项试点研究,使用扩散性曲解成像

Ning Zhang¹, Kun Peng¹, Jin-Xia Guo²

¹Department of Radiology, The Sixth Hospital of Shanxi Medical University (General Hospital of TISCO), Taiyuan, People's Republic of China.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

|April 24, 2024

概括

扩散曲解成像揭示了阻塞性睡眠呼吸暂停 (OSA) 患者的大脑异常. 在OSA患者中,平均缩症 (MK) 值较低,与认知功能缺陷相关.

科学领域:

神经成像是一种神经成像.
睡眠医学睡眠医学
神经学神经学

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 与认知障碍有关.
扩散曲解成像 (DKI) 提供了对大脑微观结构的洞察.

研究的目的:

用DKI评估中度至重度OSA患者的大脑异常.
分析OSA中平均缩症 (MK) 和认知功能之间的相关性.

主要方法:

30名OSA患者和30名对照患者接受了DKI和3D T1加权MRI.
蒙特利尔认知评估 (MoCA) 规模评估了认知功能.
部分相关性分析检查了MK,睡眠参数和认知之间的关系.

主要成果:

在13个大脑区域中,OSA患者的MK显著降低 (FDR后纠正),认知分数也降低.
呼吸暂停-呼吸暂停指数与白质MK负相关.
最低的氧和与皮层MK正相关.

结论:

由DKI衍生出的MK值可能表明OSA中的神经损伤.
MK显示了评估大脑对OSA的反应的潜力.

关键词:

认知功能认知功能扩散曲解成像扫描图像阻塞性睡眠呼吸暂停 (SOP) 的情况.

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