与男性相比,吸烟是女性下肢外周动脉疾病的风险因素:系统性审查和元分析
Ying Xu1,2, Anna Louise Pouncey3, Zien Zhou1
1Faculty of Medicine, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
PloS one
|April 24, 2024
概括
吸烟增加了边缘动脉疾病 (PAD) 的风险,无论男女. 与男性相比,女性吸烟者面临着更高的PAD风险,这表明吸烟的性别差异很大.
科学领域:
- 心血管健康 心血管健康
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 调查吸烟对周围动脉疾病 (PAD) 风险的性别差异影响.
- 解决了解性别特异性心血管疾病风险因素的差距.
研究的目的:
- 为了确定吸烟和PAD之间的关联是否因性别而异.
- 综合现有关于不同人群中吸烟和PAD风险的证据.
主要方法:
- 在PubMed,EMBASE和CINAHL数据库中的系统文献搜索.
- 来自四个队列和十三项横截面研究的汇总数据的元分析.
- 使用纽卡斯尔-太华尺度和异质性分析 (I2,Cochran's Q) 进行质量评估.
主要成果:
- 与从未吸烟相比,以前和现在的吸烟都显著增加了PAD风险.
- 目前吸烟的女性比男性 (RR 3.30) 有更高的PAD风险 (RR 5.30).
- 横截面研究显示了不同性别的风险模式,其中一些表明男性的风险更高.
结论:
- 有证据表明,吸烟与PAD关系中存在潜在的性别差异,尽管目前的数据是混合的.
- 需要进一步的研究才能充分阐明这些性别相关性.
- 烟草控制策略应该承认并解决PAD风险中的潜在性别差异.
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