简要报告:心脏多病症对COVID住院治疗结果的影响
Fouad Chouairi1, Edward Jaffe2, Abdul Mannan Khan Minhas3
1Department of Medicine, Duke University School of Medicine, Durham, NC, United States of America.
PloS one
|April 24, 2024
概括
患有更多心脏并发症的患者在COVID-19住院期间面临更高的死亡率和机械通风风险. 这项全国性研究强调了心脏病对严重COVID-19结果的关键影响.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 在全球范围内,COVID-19大流行严重压迫了医疗保健系统.
- 使用国家数据,关于心脏风险因素对COVID-19住院治疗结果的影响的研究有限.
- 心脏多病症是严重的COVID-19结果的一个重大问题.
研究的目的:
- 调查心脏多病症对医疗保健利用和COVID-19住院治疗结果的影响.
- 分析国家数据,查找心脏病并发症和COVID-19严重程度之间的关联.
- 确定心脏病是否独立影响COVID-19患者的死亡率和机械通风率.
主要方法:
- 利用国家住院样本 (NIS) 数据库在2020年成人COVID-19入院的数据.
- 使用ICD-10-CM代码识别心脏并发症,包括冠状动脉疾病,糖尿病,心力衰竭和心房动.
- 采用多变量逻辑回归来评估心脏多病症对死亡率和机械呼吸的影响.
主要成果:
- 分析了超过100万名COVID-19患者的入院情况,其中心脏伴随性疾病的患病率很高 (例如,39.4%患有糖尿病).
- 观察到一种明确的剂量反应关系:较高的心脏并发症数量与增加的死亡率和机械通风率相关 (p<0.001).
- 多变量分析证实,心脏多发病率增加独立预测了较高的死亡率 (ORs从1.48到2.43).
结论:
- 这是第一项全国性研究,研究心脏伴随性疾病对COVID-19结果的影响.
- 增加的心脏多病症与更高的机械呼吸率和住院死亡率显著相关,不论年龄.
- 建议进一步进行细粒度和纵向研究,以加深对这些关联的理解.
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