针对目标介导药物处置模型的近似值条件:一种新的第一顺序近似值及其与其他近似值的比较

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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

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Jong Hyuk Byun1,2, Hye Seon Jeon3, Hwi-Yeol Yun3,4

  • 1Department of Mathematics and Institute of Mathematical Science, Pusan National University, Busan, Republic of Korea.

PLoS computational biology
|April 24, 2024
PubMed
概括

简化目标介导药物排放 (TMDD) 模型提供了计算效率. 这项研究验证了三个模型 (mTMDD,qTMDD,pTMDD),为药物开发中准确的药理动力学预测提供了指导.

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