在患有的年轻成年人中,与甲酸撤销相关的患病和死亡风险
Gashirai K Mbizvo1,2,3, Tommaso Bucci1,4, Gregory Y H Lip1,5
1Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital, Liverpool, L69 7TX, UK.
患有的年轻成年人中断使用瓦尔酸与急诊,住院,跌倒,受伤,烧伤和抑郁症的风险增加有关. 然而,在停止服用酸的患者中没有观察到死亡风险的增加.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 酸是一种高效的治疗药物,但由于产性,其在生育年龄的女性中使用受到限制.
- 最近的指导方针将这些限制扩展到男性和55岁以下的个人,这使得许多患者需要停止服用氨酸.
- 与氨酸戒断相关的危害风险,特别是关于发病率和死亡率的风险,在两种性别中都没有得到充分量化.
研究的目的:
- 评估与患者的年轻男性和女性的氨酸戒断相关的发病和死亡风险.
- 提供数据,以告知临床咨询有关停止使用瓦尔酸盐的安全性.
主要方法:
- 一项回顾性队列研究,使用来自TriNetX全球协作网络的电子健康数据.
- 包括16-54岁的男性和女性,患有和最近的氨酸处方.
- 倾向匹配分析比较了在五年内继续服用氨酸和停止服用的患者之间死亡和发病风险的结果.
主要成果:
- 停止服用瓦尔酸与急诊室出诊,住院,跌倒,受伤,烧伤和新发抑郁症的风险显著增加有关.
- 这些结果的绝对风险增加在戒断组中高于1%至7%.
- 停止服用瓦尔酸盐与死亡风险增加无关.
结论:
- 在患有的年轻成年人中,停止服用氨酸与几种不良健康事件的风险增加有关,不包括死亡率.
- 这些发现对于使临床医生和患者之间就瓦尔酸戒断的安全影响进行知情讨论至关重要.
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