牛皮作为一种全身性疾病
Ulrich Mrowietz1, Felix Lauffer, Wiebke Sondermann
1Psoriasis Centre at the Department of Dermatology, Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel; Department of Dermatology and Allergology, Biederstein, Technical University of Munich; Department of Dermatology, Venereology, Allergology, University Hospital Essen, University Duisburg-Essen, Essen; Rheumatology center of the Ruhr area, Ruhr-University Bochum, Herne.
Deutsches Arzteblatt international
|April 24, 2024
概括
牛皮病是一种系统性炎症状况,影响皮肤,关节和动脉,而不仅仅是皮肤. 管理需要医生和患者之间的协作方法,以获得最佳的治疗策略.
科学领域:
- 皮肤病学 皮肤病学
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 牛皮,曾经被认为是一种仅仅是皮肤的炎症状况,现在被认为是一种全身性疾病,称为牛皮病.
- 来自多个研究领域的新兴数据证实了其系统性质.
研究的目的:
- 为了提供有关牛皮病的全面概述.
- 突出其系统表现及其相关条件.
- 讨论目前对其病原和治疗的理解.
主要方法:
- 选择性文献审查,重点关注临床试验和当前出版物.
- 包括国际指导方针建议.
主要成果:
- 牛皮病涉及皮肤,动脉,骨和关节的免疫介导炎症.
- 相关疾病包括高血压,代谢综合征和抑郁症.
- 肥胖是主要的危险因素,而压力和感染是常见的触发因素.
- 复杂的遗传学和特定的细胞因子参与 (IL-17,IL-23) 标志着它的炎症模式.
- 现代生物和其他疗法可以针对潜在的炎症过程.
结论:
- 牛皮病是一种复杂的系统性疾病,需要结构化的管理.
- 医生与患者的合作对于开发最佳治疗策略至关重要.
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